Electromagnetic Biology and Medicine journal: Five new papers
- Gepubliceerd: woensdag 07 augustus 2013 08:34
Extra-low-frequency magnetic fields alter cancer cells through metabolic restriction
Background: Biological effects of extra-low-frequency (ELF) magnetic fields (MFs) have lacked a credible mechanism of interaction between MFs and living material. Objectives: To examine the effect of ELF-MFs on cancer cells. Methods: Five cancer cell lines were exposed to ELF-MFs within the range of 0.025–5 µT, and the cells were examined for karyotype changes after 6 d. Results: All cancer cells lines lost chromosomes from MF exposure, with a mostly flat dose-response. Constant MF exposures for three weeks allow a rising return to the baseline, unperturbed karyotypes. From this point, small MF increases or decreases are again capable of inducing karyotype contractions (KCs). Our data suggest that the KCs are caused by MF interference with mitochondria’s adenosine triphosphate synthase (ATPS), compensated by the action of adenosine monophosphate-activated protein kinase (AMPK). The effects of MFs are similar to those of the ATPS inhibitor, oligomycin. They are amplified by metformin, an AMPK stimulator, and attenuated by resistin, an AMPK inhibitor. Over environmental MFs, KCs of various cancer cell lines show exceptionally wide and flat dose-responses, except for those of erythroleukemia cells, which display a progressive rise from 0.025 to 0.4 µT. Conclusions: The biological effects of MFs are connected to an alteration in the structure of water that impedes the flux of protons in ATPS channels. These results may be environmentally important, in view of the central roles played in human physiology by ATPS and AMPK, particularly in their links to diabetes, cancer and longevity.
Why are living things sensitive to weak magnetic fields?
Abraham R. Liboff. Why are living things sensitive to weak magnetic fields? Electromagnetic Biology and Medicine.Posted online on August 5, 2013. (doi:10.3109/15368378.2013.
There is evidence for robust interactions of weak ELF magnetic fields with biological systems. Quite apart from the difficulties attending a proper physical basis for such interactions, an equally daunting question asks why these should even occur, given the apparent lack of comparable signals in the long-term electromagnetic environment. We suggest that the biological basis is likely to be found in the weak (50 nT) daily swing in the geomagnetic field that results from the solar tidal force on free electrons in the upper atmosphere, a remarkably constant effect exactly in phase with the solar diurnal change. Because this magnetic change is locked into the solar-derived everyday diurnal response in living things, one can argue that it acts as a surrogate for the solar variation, and therefore plays a role in chronobiological processes. This implies that weak magnetic field interactions may have a chronodisruptive basis, homologous to the more familiar effects on the biological clock arising from sleep deprivation, phase-shift employment and light at night. It is conceivable that the widespread sensitivity of biological systems to weak ELF magnetic fields is vestigially derived from this diurnal geomagnetic effect.
Drosophila oogenesis as a bio-marker responding to EMF sources
Lukas H. Margaritis, Areti K. Manta, Constantinos D. Kokkaliaris, Dimitra Schiza, Konstantinos Alimisis, Georgios Barkas, Eleana Georgiou, Olympia Giannakopoulou, Ioanna Kollia, Georgia Kontogianni, Angeliki Kourouzidou. Angeliki Myari, Fani Roumelioti, Aikaterini Skouroliakou, Vasia Sykioti, Georgia Varda, Konstantinos Xenos, and Konstantinos Ziomas. Drosophila oogenesis as a bio-marker responding to EMF sources. Electromagnetic Biology and Medicine.
Posted online on August 5, 2013. (doi:10.3109/15368378.2013.800102).
The model biological organisms Drosophila melanogaster and Drosophila virilis have been utilized to assess effects on apoptotic cell death of follicles during oogenesis and reproductive capacity (fecundity) decline. A total of 280 different experiments were performed using newly emerged flies exposed for short time daily for 3–7 d to various EMF sources including: GSM 900/1800 MHz mobile phone, 1880–1900 MHz DECT wireless base, DECT wireless handset, mobile phone-DECT handset combination, 2.44 GHz wireless network (Wi-Fi), 2.44 GHz blue tooth, 92.8 MHz FM generator, 27.15 MHz baby monitor, 900 MHz CW RF generator and microwave oven’s 2.44 GHz RF and magnetic field components. Mobile phone was used as a reference exposure system for evaluating factors considered very important in dosimetry extending our published work with D. melanogaster to the insect D. virilis. Distance from the emitting source, the exposure duration and the repeatability were examined. All EMF sources used created statistically significant effects regarding fecundity and cell death-apoptosis induction, even at very low intensity levels (0.3 V/m blue tooth radiation), well below ICNIRP’s guidelines, suggesting that Drosophila oogenesis system is suitable to be used as a biomarker for exploring potential EMF bioactivity. Also, there is no linear cumulative effect when increasing the duration of exposure or using one EMF source after the other (i.e. mobile phone and DECT handset) at the specific conditions used. The role of the average versus the peak E-field values as measured by spectrum analyzers on the final effects is discussed.
Erik Aguirre, Javier Arpón, Leire Azpilicueta, Peio López, Silvia de Miguel, Victoria Ramos, and Francisco Falcone.Estimation of Electromagnetic Dosimetric Values from Non-Ionizing Radiofrequency Fields in an Indoor Commercial Airplane Environment. Electromagnetic Biology and Medicine.Posted online on August 5, 2013. (doi:10.3109/15368378.2013.
In this article, the impact of topology as well as morphology of a complex indoor environment such as a commercial aircraft in the estimation of dosimetric assessment is presented. By means of an in-house developed deterministic 3D ray-launching code, estimation of electric field amplitude as a function of position for the complete volume of a commercial passenger airplane is obtained. Estimation of electromagnetic field exposure in this environment is challenging, due to the complexity and size of the scenario, as well as to the large metallic content, giving rise to strong multipath components. By performing the calculation with a deterministic technique, the complete scenario can be considered with an optimized balance between accuracy and computational cost. The proposed method can aid in the assessment of electromagnetic dosimetry in the future deployment of embarked wireless systems in commercial aircraft.
This article discusses mutual interactions phenomena especially in the case of Transverse ElectroMagnetic (TEM) cell applications as an exposure system in technical and biomedical studies. Problem of mutual interactions between tested objects placed in the electromagnetic field (EMF) is described. A new device for exposure system is presented. Its role is elimination of mentioned harmful phenomenon that leads to falsifications of results.